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The ability of the body to utilize creatine in this manner may contribute to a leaner body. It should also be noted here that the creatine would remain in the muscle tissue for a longer time than either protein, and it would be an easy source of substrate for the cellular protein synthesis, and a major source of energy as well. Hence, the creatine should be retained by the muscle cells longer to enable longer term utilization of the energy from muscle contractions. The research above shows that the body has a way to hold glycogen in the muscle tissue longer to make additional muscle fibers in response to the higher metabolic demand that accompanies prolonged exercise. This is supported by several published experimental and mechanistic studies that have taken into account muscle adaptation to greater or shorter durations of exercise. As discussed previously, this suggests that more exercise will benefit the health of the body, especially if it is accompanied by longer recovery periods and a gradual decline in body fat mass. An important aspect for this to be taken into consideration is a long-term loading program with longer periods and shorter recovery periods for long-term maintenance of muscle strength and mass. The time periods for glycogen storage and re-use should be short. This would have the benefit of supporting the body for years of sustained use of glycogen as well as maintaining body weight (Fig. 2). This will result in greater and longer-lasting adaptation to exercise. The above conclusions may help shed some light on the different muscle hypertrophy pathways that are employed in different parts of the body. However, more research using better bio-imaging techniques will be necessary in understanding the full extent of the role that creatine can play in the muscles. 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